Proton irradiation of malignant melanoma of the ciliary body.

نویسندگان

  • E S Gragoudas
  • M Goitein
  • A Koehler
  • M S Wagner
  • L Verhey
  • J Tepper
  • H D Suit
  • R J Schneider
  • K N Johnson
چکیده

This is our first case of malignant melanoma of the ciliary body treated with proton beam irradiation, a technique that we developed for irradiating choroidal melanomas. After 21 months of follow-up no growth of the tumour has been observed, and shrinkage of the tumour was noted on the follow-up photographs and by ultrasonography. The 32P uptake test, which was positive before treatment, turned negative 14 months after irradiation. The described technique of proton beam irradiation might offer an alternative for the treatment of ciliary body melanomas when the present techniques of iridocyclectomy cannot be applied because of the size of the lesion.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ciliary body melanoma masquerading as chronic uveitis.

PURPOSE To report a case of ciliary body melanoma that masqueraded as chronic uveitis. METHODS A patient experienced persistent unilateral panuveitis and elevated intraocular pressure. Inflammation and pressure worsened after cataract extraction and lens implantation. Diagnostic vitrectomy was non-revealing. RESULTS Repeat vitrectomy and lens implant removal revealed a ciliary body mass, su...

متن کامل

Laser and proton radiation to reduce uveal melanoma-associated exudative retinal detachments.

PURPOSE To assess whether laser-induced hyperthermia in conjunction with proton irradiation of choroidal melanoma may more rapidly decrease exudative retinal detachments. DESIGN Case-control study. METHODS This was a single-center prospective phase 1 study of choroidal melanoma patients with exudative retinal detachments. These tumors did not overhang the optic disc, involve the fovea, or h...

متن کامل

Metastatic melanoma death rates by anatomic site after proton beam irradiation for uveal melanoma.

BACKGROUND Ciliary body location is an established prognostic factor for metastasis-related death from uveal melanoma. We evaluated alternative approaches for classifying this covariate when constructing predictive models of patient survival. METHODS AND DESIGN The analyses were based on a consecutive series of 1848 primary choroidal and/or ciliary body melanoma patients treated with proton b...

متن کامل

EVects of proton beam irradiation on uveal melanomas: a comparative study of Ki-67 expression in irradiated versus non-irradiated melanomas

Aims—To assess the cellular proliferation using the monoclonal antibody Ki-67, in paraYn embedded uveal melanomas irradiated by proton beam, as well as in non-irradiated uveal melanomas. Methods—30 enucleated eyes were included for histopathological study and Ki-67 immunostaining. Patients were enucleated between 1991 and 1996 for uveal melanoma, 14 after proton beam irradiation and 16 without ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The British journal of ophthalmology

دوره 63 2  شماره 

صفحات  -

تاریخ انتشار 1979